John Silberholz

 

Faculty Candidate John Silberholz  [MIT] 
Title An Analytics Approach to Designing Drug Therapies for Cancer
Date & Time Friday, February 10, 2017
Place UCLA Anderson School of Management 
Room A021

 

Abstract
Worldwide, cancer is a leading cause of death, and metastatic breast cancer (MBC) is the top cause of cancer death among women. We present a data-driven approach to planning clinical trials and designing novel drug therapies for metastatic breast cancer. First, we describe construction of a large database of MBC clinical trial results and tools to help clinicians visualize the data. Next, we use statistical models to predict efficacy and toxicity outcomes of trials before they are run, with implications for selecting between multiple drug therapies for testing. Finally, we use optimization models to design novel therapies that strike a balance between improving patient outcomes and learning about new drugs; we present evidence that these models may improve trial outcomes compared to current practice.

John Silberholz